What is Liposomal Vitamin C? Benefits & How it Works

From the benefits for your skin to the extra immune support, there is a multitude of reasons for the rising popularity of Liposomal Vitamin C supplements – but what actually is it? Here’s everything you need to know about Liposomal Vitamin C and why people are switching out their capsules.

First of all, there is no difference in the Vitamin C itself – the only difference between Liposomal Vitamin C supplements and normal vitamin C supplements is that instead of just taking vitamin C in its raw form, the vitamin C is encapsulated in something called ‘Liposomes’. It turns out encapsulating vitamin C in these liposomes can have a big effect.

What are Liposomes?

Liposomes are made up from a bi-layer of phospholipids – it’s essentially a layer of ‘fat’ that surrounds the vitamin C. And no, it isn’t bad for you. These phospholipids are the same things that surround our cells – they keep our cells together and contained, stopping things from getting in or out.

The phospholipids have two parts – a hydrophilic head and a hydrophobic tail. This polar nature of phospholipids means a bi-layer can form that completely surrounds the Vitamin C. Like a magnet, the hydrophobic tails are attracted to each other and the hydrophilic heads are repelled by each other. By wrapping the vitamin C in this phospholipid bi-layer, it ensures nothing can get at the Vitamin C and the Vitamin C can’t escape – the vitamin C is ‘encapsulated’.

Liposomal Vitamin C VS. Regular Vitamin C

So when you take a Liposomal vitamin C product over a regular Vitamin C product, what you’re actually doing is taking Vitamin C that is surrounded by a layer of fat (and no… it isn’t bad for you). But why should this make such a big difference? By encapsulating Vitamin C in liposomes, it can actually have a big impact on how the Vitamin C interacts with your digestive system as well as how the vitamin C is delivered into your cells. The liposomes increase the bioavailability of the vitamin C.

Liposomes as a shield

A liposome is a tiny sphere that carries ingredients. Made up from a phospholipid bi-layer, the outside shell encapsulates the vitamin C forming a tiny bubble that shields it from the outside. When you take traditional vitamin C supplements, some of it gets lost during the digestion process and even less actually makes it to your cells. The liposomal shield ensures as much Vitamin C as possible makes it into your bloodstream.

Liposomal delivery

Once the liposomes have transported the vitamin C through your digestive system and into your body, they will deliver the vitamin C directly into the cells themselves. Vitamin C is water-soluble: it has trouble getting into a cell through a cell membrane which is fat based. Liposomes overcome this by merging with the cell membrane of your cell, transferring its contents to the inside of the cell. By using liposomes to transport Vitamin C, we can ensure that as much Vitamin C as possible makes it to the cells that need it.

The Benefits of Liposomal Vitamin C

Energy, tiredness & fatigue
Vitamin C contributes to the reduction of tiredness & fatigue
Vitamin C contributes to normal collagen formation for the normal function of skin
Immune health
Vitamin C contributes to the normal function of the immune system

Vitamin C for your Skin

Studies have found that higher intakes of vitamin C from the diet are associated with better skin appearance, highlighting differences in skin wrinkling (4,5). This shouldn’t come as much of a surprise to scientists: Vitamin C is concentrated in both the outer layer of the skin (the epidermis) and the inner layer of the skin (the dermis) (1), and for some reason, as we age, the concentration of Vitamin C in our skin cells decreases (2). One way we can fight this caveat of ageing is through supplementation - studies show that oral supplementation of vitamin C increases vitamin C concentration in the skin (3).

Vitamin C stimulates the production of collagen, the scaffolding that holds up the skin. The role of vitamin C in regulating the synthesis of collagen is well documented (6). Collagen is a protein that lies beneath the skin, providing structure and support and is responsible for strength and elasticity – without it our skin would be really saggy. As we age, our collagen production slows down – by about 1% every year after the age of 20 – which leads to wrinkles and sagging skin no matter which moisturiser you use.

Vitamin C prevents UV damage through its antioxidant properties. Free radicals are one of the leading causes of aging skin and are caused by UV light from the sun. These highly reactive compounds attack the building blocks that make up our cells, and can breakdown the collagen in your skin encouraging wrinkles and sagging. Antioxidants neutralise these free radicals so they can’t attack your cells, travelling through your body ‘donating’ electrons to free radicals to protect your body from UV damage. Vitamin C is not only one of these antioxidants, but one of the most powerful – with the capability to donate two electrons rather than one.

Dry skin. Water is constantly flowing through the layers of our skin and evaporating into the air in a process known as ‘Trans Epidermal Water Loss’. Higher intake of dietary vitamin C has been correlated with a decreased risk of dry skin (7), suggesting that vitamin C may have effects on this process that continually sees water leaving our skin cells. Although not fully understood, it has been shown in laboratories through the use of cell culture models that the addition of vitamin C promotes the synthesis of barrier lipids, which would establish a skin with higher water retention (8,9).

Vitamin C for your immune system

One of the most popular reasons to supplement with Vitamin C is to help bolster your immune system. Whenever your cells come under stress or infection, your immune cells go into overdrive - they pump in vitamin C to achieve vitamin C levels 100x that of the blood (11,12). While good at fighting infections, it’s hard to sustain. Your immune cells are designed to pump in vitamin C whenever they need it at very short notice, but since our body can’t make or store vitamin C, our body must make do with what we’ve eaten the previous day. So just when you need extra vitamin C, your body’s stores are depleted. The fact of it is that most of us just don’t get enough vitamin C in our daily diets to satiate an active immune system; around 23% of Americans suffer vitamin C depletion, causing their immune systems to not function properly (17). Fortunately, you can improve your immune system’s function by supplementing with vitamin C (13,14,15,16). In fact, studies have shown that Vitamin C supplementation can reduce the duration of colds by up to 21%, and actually reduce cold incidence by up to 50% among people undergoing heavy stress (19,20,21).

Vitamin C for reducing tiredness & fatigue

Tiredness & fatigue is one of the most prevalent complaints in healthy adults - studies have found that up to 27% of adults experience fatigue, defined as “extreme tiredness resulting from mental or physical exertion or illness”. It’s a significant chunk of the population and a problem that can ruin your whole day, which is probably why it’s been focussed on so heavily in the research of supplements. One of the most promising studies comes from Korea, where 141 healthy volunteers participated in a randomised, double-blind, controlled clinical trial testing the efficacy of Vitamin C in reducing fatigue. The Vitamin C was administered intravenously, that is, it was injected straight into a vein, and managed to reduce fatigue after two hours with the effects persisting for a whole day. Why was it administered straight into a vein? Because oral Vitamin C has historically poor bioavailability (is poorly absorbed) when taken through the digestive system. The availability of Liposomal Vitamin C supplements however has meant that this has started to change. Because the Liposomes protect and deliver the Vitamin C to your cells, the fatigue fighting benefits of Vitamin C can now be harnessed with supplements and not just when intravenously administered.

Bones & cartilage
Vitamin C contributes to the normal function of bones & cartilage
Oxidative stress
Vitamin C contributes to the protection of cells from oxidative stress
Psychological function
Vitamin C contributes to normal psychological function
Iron absorption
Vitamin C increases iron absorption



Try Liposomal Vitamin C Now

  • One sachet of Vitamin C Zooki contains 1000mg of Liposomal Vitamin C
  • Patented technology – the bioavailability and clean label of Vitamin C Zooki is made possible by patented “nano-encapsulation” technology.
  • Have straight or mix with water – mixes effortlessly with water and completely dissolves. Can also be enjoyed straight from the sachet.
  • Pure, natural ingredients – does not contain: alcohol, soy, dairy, gluten, wheat, sugar or artificial preservatives such as potassium sorbate.
  • Vitamin C Zooki is also completely VEGAN FRIENDLY and NON-GMO. We use organic, plant based glycerin which naturally preserves the ingredients and sweetens the taste. We use natural orange oils for the citrus flavour.


  1. Shindo Y, Witt E, Han D, Epstein W, Packer L. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994;102:122-124.
  2. Rhie G, Shin MH, Seo JY, et al. Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo. J Invest Dermatol 2001;117:1212-1217
  3. McArdle F, Rhodes LE, Parslew R, Jack CI, Friedmann PS, Jackson MJ. UVR-induced oxidative stress in human skin in vivo: effects of oral vitamin C supplementation. Free Radic Biol Med 2002;33:1355-1362.
  4. Peterkofsky B. Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Am J Clin Nutr 1991;54:1135S-1140S.
  5. Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr 2007;86:1225-1231
  6. Purba MB, Kouris-Blazos A, Wattanapenpaiboon N, et al. Skin wrinkling: can food make a difference? J Am Coll Nutr 2001;20:71-80
  7. Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr 2007;86:1225-1231.
  8. Savini I, Catani MV, Rossi A, Duranti G, Melino G, Avigliano L. Characterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis. J Invest Dermatol 2002;118:372-379
  9. Ponec M, Weerheim A, Kempenaar J, et al. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 1997;109:348-355
  10. Pavlovic V. A short overview of vitamin C and selected cells of the immune system. Cent. Eur. J. Med. 2010 October;8(1):1-10.
  11. Strohle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63
  12. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94.
  13. Johnston CS, Barkyoumb GM, Schumacher SS. Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Nutrients. 2014 Jul;6(7):2572-83.
  14. Delafuente JC, Prendergast JM, Modigh A. Immunologic modulation by vitamin C in the elderly. Int J Immunopharmacol. 1986;8(2):205-11.
  15. Mikirova N, Hunninghake R. Effect of high dose vitamin C on Epstein-Barr viral infection. Med Sci Monit. 2014;20:725-32.
  16. Hampl JS, Taylor CA, Johnston CS. Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994. Am J Pub Health. 2004 May;94(5):870-5
  17. Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep;3(9):756-61
  18. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94.
  19. Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep;3(9):756-61
  20. Hemila H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med. 1996 Jul;17(5):379-83.


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